The dysregulated pathway that drives us low and high

Bipolar disorder refers to a chronic condition that consists of mood swings between two different mood poles, the high pole (mania) and the low pole (depression). In the course of their illness, bipolar patients may endure an increase in the frequency and severity of symptoms termed progression. Inflammation is the most potent biological mechanism to explain this progression, however, thus far no specific mechanism was identified. The over activation of immune response, observed in bipolar patients, may be due to the dysregulation of Nf-kb, a key regulator of the immune system.

In Elhaik and Zandi 2015, we wrote the first review of NF-kB’s involvement in bipolar disorder. We concluded that there is evidence that NF-kB dysregulation is an important factor in the etiology of BD and related psychiatric disorders.

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